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Symposium on 'Technologies in Carcinogenesis and Chemoprevention'

May 30-31, 2013

Venue: James Graham Brown Cancer Center

Coordinated by Manicka V. Vadhanam, MNVR Kumar (UK) and Jamal M. Arif (Saudi Arabia)

 

 
Cancer is one of the leading causes of mortality worldwide. The multifocal and multiple-pathways based carcinogenesis process with relatively longer latency period has proven a great challenge to develop a cure.  The development of new technologies has provided countless biomarkers in numerous pathways leading to the initiation, development and/or progression of cancer. Consequently, these biomarkers and pathways have provided diversified approach of inhibiting or delaying the cancer development. Though all the three major events in the carcinogenesis process play significant role in the cancer development, initiation, a possible pre-requisite of cancer development might be relatively more crucial step in the induction of genomic instability.  One of the basic events to induce genomic instability is the formation of DNA adducts which have been considered to be an intermediary biomarker in cancer development. Formation of various carcinogen-specific DNA adducts with exogenous and/or endogenous carcinogens depend on their metabolic activation and detoxification while the removal and persistence of these adducts are partially controlled by efficiency of DNA repair mechanism(s).  DNA adducts are considered as reliable biomarkers in the early detection of cancers, biomonitoring to environmental exposures and screening of natural and synthetic compounds for cancer chemopreventive potential, however; their efficient detection and characterization was a real daunting task.
 
With the emergence of revolutionary and innovative 32P-postlabeling technique co-developed by Prof. Ramesh C. Gupta in 1982, DNA adduct measurement with precise detection limit of 1 adduct per 109-10 nucleotides has become a routine analysis. With time, this technique was improved and adapted for analysis of various types of DNA adducts by numerous laboratories worldwide, for which he was featured on Cancer Research Cover Page in February 1990.  Even though there have been several other techniques e.g. HPLC, GC-MS, CE-MS, LC-MS developed for DNA adduct measurement, 32P-postlabeling technique is still one of the most utilized techniques requiring sub-microgram quantities of DNA.  However, the latter techniques have complemented the 32P-postlabeling technique to overcome one of the inherent drawbacks of 32P-postlabeling technique’s inability of establishing structural identity of DNA adducts. Prof. Gupta also has made notable contributions in cancer chemoprevention in general and off late the biodegradable implantable delivery systems that are capable of releasing the chemopreventive agents from days to months.
 
To commemorate Prof. R. C Gupta on his 65th birthday, a special issue in Cancer Letters, titled Technologies in Carcinogenesis and Chemoprevention is under way which will be released during this symposium. Dr. Gupta holds the Agnes Brown Duggan Chair in Oncological Research. He is a Distinguished University Scholar and Professor in the Department of Pharmacology and Toxicology. NIH grants, the Duggan Endowment and James Graham Brown Cancer Center have supported his research. Dr. Gupta has published more than 150 peer-reviewed papers, 20 book chapters and more than 225 abstracts. Scholars have cited his research articles more than 6,000 times.
 
The Symposium is free to attend. Please register using the link at the left.
 
 Recordings of Symposium (coming soon)

 

Program:

 
 
Time
Activity
Speaker
Title
 
 
Day 1, May 30, 2013
8:00 am     Breakfast
8:45 am
Inaugural
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Jesse Roman, MD, Professor and Chair, Department of Medicine;
David Hein, PhD, Prof. & Chair, Dept. of Pharmacology & Toxicology.
 Inaugural Address by Dr Roman and release of Special Issue of Cancer Letters on “Technologies in Carcinogenesis and Chemoprevention” by Dr Hein.
9:00 am
Keynote
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Gary Stoner, Professor, Medical College of Wisconsin
 
10:00 am
Invited
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David Phillips, Professor, King's College London, UK
Clues to cancer etiology and carcinogenic mechanisms derived from DNA adducts and other biomarkers
 
10:45 am Coffee Break​ ​ ​
11:15 am
Invited
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Gabriele Ludewig /Larry Robertson, Professor, Dept. of Occupational and Environmental Health, The University of Iowa College of Public Health
Everybody knew that PCBs are not genotoxic – until they were
12:01 pm
Invited
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Igor Progribny, Professor, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences
 
Epigenetic alterations in chemical carcinogenesis
12:45 pm   Lunch 
 
 
1:45 pm
Invited
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Stephen Nesnow, Retired Senior Scientist, National Health and Environmental Effects Research Laboratory, USEPA
Integration of toxicological approaches with “omic” and related technologies to elucidate mechanisms of carcinogenic action: Propiconazole, an example
2:30 pm
Invited
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Margie Clapper, Professor and Co-Leader, Cancer Prevention and Control, Fox Chase Cancer Center
Estrogen metabolism within the lung and its modulation by tobacco smoke
​3.15 pm Coffee break​ ​ ​
3:45 pm
Invited
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Bala Nagarajan, Professor, Cancer Institute, Chennai, India
Biomolecular markers  prognosticate human cervical cancer
4:30 pm
Invited
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Ritu Aneja, Associate Professor, Department of Biology, Georgia State University
Old paradox, new paradigms---Centrosome declustering counters clever tricks of the tumor evolutionary trade
 
 
 
 
 
 
 
 
Time
Activity
Speaker
Title
Day 2, May 31, 2013
8:00 am    Breakfast
9:00 am
Keynote
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Hassan Mukhtar, Helfaer Professor of Cancer Research, Department of Dermatology, University of Wisconsin
Making chemoprevention a success story for controlling human cancer
10:00 am
Invited
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Maarten Bosland, Professor, Department of Pathology, University of Illinois at Chicago
The role of estrogen in hormone-induced prostate carcinogenesis: Potential targets for chemoprevention?
​10.45 am ​Coffee break
11:15 am
Invited
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Santosh Katiyar, Professor, Department of Dermatology, Univ. of Alabama
Prevention of melanoma invasion by targeting ß-catenin
 
12:01pm
Invited
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Howard Glauert, Professor, Graduate Center for Nutritional Sciences, University of Kentucky
 
Prevention of lung cancer by nutritional supplements
 
12:45 pm
Lunch
1:45 pm
Invited
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Rajendra Mehta, Professor of Biological Sciences, Illinois Institute of Technology
Vitamin D and breast cancer: Emerging concepts
2:30 pm
Invited
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Inder Pal Singh, Associate Professor, National Institute of Pharmaceutical Education and Research, Punjab, India
Natural product based drug discovery
​3:15 pm Coffee break​
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Vibha Tandon, Associate Professor, Department of Chemistry, University of Delhi, India 

Dimethoxy phenyl Bisbenzimidazole Mitigates Radiation Induced DNA Damage through Activation of AKT/NFKB Signalling Pathways in Cells during Radiotherapy.
4:30 pm
 
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Concluding remarks:
 

 
 
 
 






 
Sponsors:
 
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This symposium is endorsed by Society of Free Radical Research International (http://www.sfrr.org)
 

   
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